Jones, P.T., Dear, P.H., Foote, J., Neuberger, M.S. and Winter, G. (1986) Replacing the complementarity-determining regions in a human antibody with those from a mouse  Nature 321, 522-525.PDF

Dear, P.H. and Cook, P.R. (1989) HAPPY mapping - a proposal for linkage mapping the human genome   Nucleic Acids Res. 17, 6795-6807. PDF

Dear, P.H. and Cook, P.R. (1991) Cellular gels - purifying and mapping long DNA molecules  Biochem. J. 273, 695-699. PDF

Dear, P.H. and Cook, P.R. (1993) HAPPY mapping - linkage mapping using a physical analog of  meiosis   Nucleic Acids Res. 21, 13-20. PDF

Walter, G., Tomlinson, I.M., Cook, G.P., Winter, G., Rabbitts, T.H. and Dear, P.H. (1993) HAPPY mapping of a YAC reveals alternative haplotypes in the human immunoglobulin Vh locus   Nucleic Acids Res., 21, 4524-4529. PDF

Walter, G., Tomlinson, I.M., Dear, P.H., Sonnhammer, E.L.L., Cook, G.P. and Winter, G. (1995) Comparison of the human germline and rearranged Vh repertoire reveals complementarity between germline variability and somatic mutation   Ann. N.Y. Acad. Sci. 764, 180-182. PDF

Tomlinson, I.M., Walter, G., Jones, P.T., Dear, P.H., Sonnhammer, E.L.L. and Winter, G. (1996) The imprint of somatic hypermutation on the repertoire of human germline V genes  J. Mol. Biol. 256, 813-817. PDF

Trusov, Y.A. and Dear, P.H. (1996) A molecular clock based on the expansion of gene families  Nucleic Acids Res. 24, 995-999. PDF

Dear, P.H., Bankier, A.T. and Piper, M.B. (1998) A high-resolution metric HAPPY map of human chromosome 14   Genomics 48, 232-241PDF

























Lynch, R., Piper, M., Bankier, A.T., Bhugra, B., Surti, U., Liu, J., Buckler, A., Dear, P.H., and Menon, A.G. (1998) Genomic and functional map of the t(12;14) breakpoint cluster region in uterine leiomyoma  Genomics 52, 17-26. PDF

Deming, M.S., Dyer, K.D., Bankier, A.T., Piper, M.B., Dear, P.H. and Rosenberg, H.F. (1998) Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily  Genome Research 8, 599-607. PDF

Piper, M.B., Bankier, A.T. and Dear, P.H. (1998) Construction and characterization of a genomic PAC library of the intestinal parasite Cryptosporidium parvum.  Mol. Biochem. Parasitol 95, 147-151. PDF

Piper, M.B., Bankier, A.T. and Dear, P.H. (1998)  A HAPPY map of Cryptosporidium parvum.  Genome Res. 8, 1299-1307. PDF

Biunno, I., Bernard, L., Dear, P., Cattaneo, M., Volorio, S., Zannini, L., Bankier, A. and Zollo, M. (2000) SEL1, the human homolog of C. elegans sel-1: refined physical mapping, gene structure and identification of polymorphic markers. Hum. Genet. 106, 227-235. PDF

Konfortov, B.A., Cohen, H.M., Bankier, A.T. and Dear, P.H. (2000) A high-resolution HAPPY map of Dictyostelium discoideum chromosome 6.  Genome Res. 10, 1737-1742. PDF

Amar, C. F., Dear, P.H., Pedraza-Diaz, S., Looker, N., Linnane, E. and McLauchlin, J.  (2002)  Sensitive PCR-restriction fragment length polymorphism assay for detection and genotyping of Giardia duodenalis in human feces. J Clin Microbiol. 40, 446-452. PDF

Glöckner, G., Eichinger, E., Szafranski K., Pachebat, J.A., Bankier, A.T., Dear, P.H., Lehmann, R., Baumgart, C., Parra, G., Abril, J.F., Guigó, R., Kumpf, K., Tunggal, B., the Dictyostelium Genome Sequencing Consortium, Cox, E., Quail, M., Platzer, M., Rosenthal, A. and Noegel, A.A.  (2002) Sequence and Analysis of Chromosome 2 of Dictyostelium discoideum. Nature 418, 79-85. PDF

Waugh, R., Dear, P.H., Powell, W. and Machray, G.C. (2002)  Physical education - new technologies for mapping plant genomes.  Trends Plant Sci. 7, 521









Hall, N., Pain, A., Berriman, M., Churcher, C., Harris, B., Harris, D., Mungall, K., Bowman, S., Atkin, R., Baker, S., Barron, A., Brooks, K., Buckee, C.O., Burrows, C., Cherevach, I., Chillingworth, C., Chillingworth, T., Christodoulou, Z., Clark, L., Clark, R., Corton, C., Cronin, A., Davies, R., Davis, P., Dear, P., Dearden, F., Doggett, J., Feltwell, T., Goble, A., Goodhead, I., Gwilliam, R., Hamlin, N., Hance, Z., Harper, D., Hauser, H., Hornsby, T., Holroyd, S., Horrocks, P., Humphray, S., Jagels, K., James, K.D., Johnson, D., Kerhornou, A., Knights, A., Konfortov, B., Kyes, S., Larke, N., Lawson, D., Lennard, N., Line, A., Maddison, M., McLean, J., Mooney, P., Moule, S., Murphy, L., Oliver, K., Ormond, D., Price, C., Quail, M.A., Rabbinowitsch, E., Rajandream, M.A., Rutter, S., Rutherford, K.M., Sanders, M., Simmonds, M., Seeger, K., Sharp, S., Smith, R., Squares, R., Squares, S., Stevens, K., Taylor, K., Tivey, A., Unwin, L., Whitehead, S., Woodward, J., Sulston, J.E., Craig, A., Newbold, C. and Barrell, B.G. (2002) Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.  Nature 419, 527-531. PDF

Thangavelu, M., James, A.B., Bankier, A., Bryan, G.J., Dear, P.H. and Waugh, R. (2003) HAPPY mapping in a plant genome: reconstruction and analysis of a high-resolution physical map of a 1.9Mbp region of Arabidopsis thaliana chromosome 4  Plant Biotech. J. 1, 23-31.PDF

Dear, P.H. (2003) One by one: single-molecular tools for genomics. Briefings in Functional Genomics 1, 397-416. PDF

Amar, C.F.L., Dear, P.H. and McLauchlin, J. (2003) Detection and genotyping by real-time PCR/RFLP analyses of Giardia duedenalis from human faeces. J. Med. Microbiol. 52, 681-683. PDF

Bankier, A.T., Spriggs, H.F., Fartmann, B., Konfortov, B.A., Madera, M., Vogel, C., Teichmann, S.A., Ivens, A. and Dear, P.H. (2003) Integrated mapping, chromosomal sequencing and sequence analysis of Cryptosporidium parvum.  Genomics 1, 1787-99. PDF

Amar, C.F.,  Dear,  P.H. and McLauchlin, J. (2004)  Detection and identification by real time PCR/RFLP analyses of Cryptosporidium species from human faeces.  Lett. Appl. Microbiol. 38, 217-22. PDF






Abrahamsen, M.S., Templeton, T.J., Enomoto, S., Abrahante, J.E., Zhu, G., Lancto, C.A., Deng, M., Liu, C., Widmer, G., Tzipori, S., Buck, G.A., Xu, P., Bankier, A.T., Dear, P.H., Konfortov, B.A., Spriggs, H.F., Iyer, L., Anantharaman, V., Aravind, L., and Kapur, V. (2004) Complete genome sequence of the apicomplexan, Cryptosporidium parvumScience. 304, 441-445. PDF

Shirley, M.W., Ivens, A., Gruber, A., Madeira, A.M., Wan, K.L., Dear, P.H., and Tomley, F.M.  (2004)  The Eimeria genome projects: a sequence of events. Trends Parasitol. 20, 199-201. PDF

Xu, P., Widmer, G., Wang, Y., Ozaki, L.S., Alves, J.M., Serrano, M.G., Puiu, D., Manque, P., Akiyoshi, D., Mackey, A.J., Pearson, W.R., Dear, P.H., Bankier, A.T., Peterson, D.L., Abrahamsen, M.S., Kapur, V., Tzipori, S. and Buck, G.A. (2004) The genome of Cryptosporidium hominis. Nature 431, 1107-1112. PDF

L. Eichinger, J.A. Pachebat, G. Glöckner, M.-A. Rajandream, R. Sucgang, M. Berriman, J. Song, R. Olsen, K. Szafranski, Q. Xu, B. Tunggal, S. Kummerfeld, M. Madera, B. A. Konfortov,  F. Rivero, A. T. Bankier,  R. Lehmann, N. Hamlin, R. Davies, P. Gaudet, P. Fey , K. Pilcher, G. Chen, D. Saunders, E. Sodergren, P. Davis, A. Kerhornou, X. Nie, N. Hall, C. Anjard, L. Hemphill, N. Bason, P. Farbrother, B. Desany, E. Just, T. Morio, R. Rost,  C. Churcher, J. Cooper, S. Haydock, N. van Driessche, A. Cronin, I. Goodhead, D. Muzny, T. Mourier, A. Pain, M. Lu, D. Harper, R. Lindsay, H. Hauser, K. James, M. Quiles, M. Madan Babu, T. Saito, C. Buchrieser, A. Wardroper, M. Felder, M. Thangavelu, D. Johnson, A. Knights, H. Loulseged, K. Mungall, K. Oliver, C. Price, M.A. Quail, H. Urushihara,  J. Hernandez, E. Rabbinowitsch, D. Steffen, M. Sanders, J. Ma, Y. Kohara, S. Sharp, M. Simmonds, S. Spiegler, A. Tivey, S. Sugano, B. White, D. Walker, J. Woodward, T. Winckler, Y. Tanaka, G. Shaulsky, M. Schleicher, G. Weinstock, A. Rosenthal, E.C. Cox, R. L. Chisholm, R. Gibbs, W. F. Loomis, M. Platzer, R. R. Kay, J. Williams, P. H. Dear, A. A. Noegel, B. Barrell and A. Kuspa (2005) The genome of the social amoeba Dictyostelium discoideum. Nature 435, 43-57. PDF

Daser, A., Thangavelu, M., Pannell, R., Forster, A., Sparrow, L., Chung, G., Dear, P.H. and Rabbitts, T.H. (2006) Interrogation of genomes by molecular copy-number counting (MCC) Nature Methods 3, 447-453. PDF

Hamilton, E.P., Dear P.H., Rowland, T., Saks, K., Eisen, J.A. and Orias, E. (2006) Use of HAPPY mapping for higher order assembly of the Tetrahymena genome. Genomics 88, 443-451. PDF

Krause, J.,  Dear, P.H.,  Pollack, J.L., Slatkin, M. ,Spriggs, H., Barnes, I., Lister, A.M., Ebersberger, I.,Pääbo, S. and Hofreiter, M. (2006) Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae.  Nature 439, 724-727.























Rompler, H., Dear, P.H., Krause, J., Meyer, M., Rohland, N., Schoneberg, T., Spriggs, H., Stiller, M. and Hofreiter, M. (2006) Multiplex amplification of ancient DNA. Nat. Protoc. 1, 720-728. PDF

Konfortov, B.A., Bankier, A.T. and Dear, P.H. (2007) An efficient method for molecular haplotyping.  Nucleic Acids Res. 35, e6. PDF

Ling, K.H., Rajandream, M.A., Rivailler, P., Ivens, A., Yap, S.J., Madeira, A.M., Mungall, K., Billington, K., Yee, W.Y., Bankier, A.T., Carroll, F., Durham, A.M., Peters, N., Loo, S.S., Isa, M.N., Novaes, J., Quail, M., Rosli, R., Nor Shamsudin, M., Sobreira, T.J., Tivey, A.R., Wai, S.F., White, S., Wu, X., Kerhornou, A., Blake, D., Mohamed, R., Shirley, M., Gruber, A., Berriman, M., Tomley, F., Dear, P.H. and Wan, K.L. (2007) Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization.  Genome Res. 17, 311-319. PDF

McCaughan, F., Darai-Ramqvist, E., Bankier, A.T., Konfortov, B.A., Foster, N., George, P.J., Rabbitts, T.H., Kost-Alimova, M., Rabbitts, P.H. and Dear, P.H.  (2008) Microdissection molecular copy-number counting (microMCC) - unlocking cancer archives with digital PCR. J Pathol. 216, 307-16. PDF

Krause, J., Unger, T., Noçon, A., Malaspinas, A.S., Kolokotronis, S.O., Stiller, M., Soibelzon, L., Spriggs, H., Dear, P.H., Briggs, A.W., Bray, S.C., O'Brien, S.J., Rabeder, G., Matheus, P., Cooper, A., Slatkin, M., Pääbo, S. and Hofreiter, M. (2008)  Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary.  BMC Evol. Biol. 8, 220. PDF

Amar, C.F., Arnold, C., Bankier, A., Dear, P.H., Guerra, B., Hopkins, K.L., Liebana, E., Mevius, D.J. and Threlfall, E.J. (2008)  Real-time PCRs and fingerprinting assays for the detection and characterization of Salmonella Genomic Island-1 encoding multidrug resistance: application to 445 European isolates of Salmonella, Escherichia coli, Shigella, and Proteus. Microb. Drug. Resist. 14, 79-92. PDF

Dear, P.H. (2009) Copy-number variation: the end of the human genome? Trends Biotech. 27, 448-454. PDF

McCaughan, F. and Dear, P.H. (2010) Single-molecule genomics. J. Pathol. 220, 297-306.PDF

Vu, G.T., Dear, P.H., Caligari, P.D. and Wilkinson, M.J. (2010) BAC-HAPPY mapping (BAP mapping): a new and efficient protocol for physical mapping. PLoS One 8, e9089. PDF
















Ramsay, N., Jemth, A.-S., Brown, A., Crampton, N., Dear, P. and Holliger, P. (2010) CyDNA: Synthesis and Replication of Highly Cy-Dye Substituted DNA by an Evolved Polymerase. J. Amer. Chem. Soc.,132, 5096-5104. PDF

McCaughan, F., Pole, J.C., Bankier, A.T., Konfortov, B.A., Carroll, B., Falzon, M., Rabbitts, T.H., George, P.J., Dear, P.H. and Rabbitts, P.H. (2010) Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer. Am. J. Respir. Crit. Care Med., 182, 83-9. PDF

McCaughan, F., Pipinikas, C.P., Janes, S.M., George, P.J., Rabbitts, P.H. and Dear, P.H. (2011) Genomic evidence for pre-invasive clonal expansion, dispersal and progression in bronchial dysplasia. J. Pathol. 224, 153-159. PDF

Pole, J.C., McCaughan, F., Newman, S., Howarth, K.D., Dear, P.H. and Edwards, P.A. (2011) Single-molecule analysis of genome rearrangements in cancer. Nucleic Acids Res. 39, e85.PDF

Miraldo, A., Hewitt, G.M., Dear, P.H., Paulo, O.S. and Emerson, B.C. (2012) NUMTS help to reconstruct the demographic history of the ocellated lizard (Lacerta lepida) in a secondary contact zone. Mol. Ecol. 21, 1005-1018.PDF

Lim, L.S., Tay, Y.L., Alias, H., Wan, K.L. and Dear, P.H. (2012) Insights into the genome structure and copy-number variation of Eimeria tenella. BMC Genomics 13:389.PDF

Day, E., Dear, P.H. and McCaughan, F. (2012) Digital PCR strategies in the development and analysis of molecular biomarkers for personalized medicine. Methods, 59, 101-107.PDF

Ali, H., Daser, A., Dear, P., Wood, H., Rabbitts, P. and Rabbitts, T. (2012) Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription. Genes Chromosomes Cancer PDF

Day, E., Poulogiannis, G., McCaughan, F., Mulholland, S., Arends, M., Ibrahim, A.E.K. and Dear, P.H. (2013) IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer. Int. J. Exp. Path. PDF





















Dear, P.H. (ed.) (1997) Genome Mapping: A Practical Approach IRL Press, Oxford. Amazon

Cooper, D.N. et al (eds) (2003) Nature Encyclopedia of the Human Genome Nature Publishing Group  (Area Editor mapping and sequencing). Amazon

Dear, P.H. (ed.) (2007) Bioinformatics:  Methods Express Scion Press, Oxford. Amazon

Book chapters:

Dear, P.H. (2003) Single-molecule PCR – basic protocols and applications in “PCR Technology – Current Innovations”, pp245-257, 2nd Edn. (Eds. Weissensteiner, T., Griffin, H. and Griffin, A.), CRC Press

Dear, P.H. (2003) 12 articles in: Encyclopedia of the Human Genome. Nature Publishing Group.



















US 20040248153A1 , US 2005/0003379 and US 20040224324A1 relate to genome mapping

US 20090191556A1 describes a method for determining copy-number

US 20010023012A1 describes a modular gel casette